Part II

Drug and Design Discovery

9

Biomarker-Based Drug Discovery with Reverse Translational

Approach . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

123

Ramesh K. Goyal and Geeta Aggarwal

10

Nanotechnology in Dentistry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

141

Krishan Gauba, Arpit Gupta, and Shweta Sharda

11

Nanoparticles: A Potential Breakthrough in Counteracting

Multidrug-Resistant Bacterial Infections—A Holistic View

on Underlying Mechanisms and Antibacterial Properties . . . . . . . .

153

Ankush Parmar and Shweta Sharma

12

Emerging Role of Cannabinoid System Modulators in

Treatment of Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

179

Sheetal Singh, Smita Pattanaik, Ravimohan S. Mavuduru,

and Shrawan Kumar Singh

13

Nanodrugs: A Futuristic Approach for Treating Nephrolithiasis . . .

203

Gupta Shruti and Kanwar Shamsher Singh

14

Lipodermaceuticals: Technological Transformations . . . . . . . . . . .

213

Rakesh Kumar Paul, Gajanand Sharma, Kaisar Raza,

and Om Prakash Katare

15

The Importance of Drug Dose Adjustment in Elderly Patients

with Special Considerations for Patients on Diverse

Co-medications and Antidepressants . . . . . . . . . . . . . . . . . . . . . . . .

231

Manju Bhaskar, Istvan G. Telessy, and Harpal S. Buttar

16

Role of Microfluidics and Nanofluidics in Managing CAD . . . . . . .

273

K. Tankeshwar and Sunita Srivastava

17

Targeted Gene Delivery Through Magnetofection:

The New Face of Medicine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

303

Jagmohan Singh, Ipsita Mohanty, R. C. Sobti, and Satish Rattan

18

QbD-Steered Systematic Development of Drug Delivery

Nanoconstructs: Vital Precepts, Retrospect and Prospects . . . . . . .

315

Bhupinder Singh, Teenu Sharma, Ranjot Kaur, Sumant Saini,

Ripandeep Kaur, and Sarwar Beg

19

Nanoemulsions: A Potential Advanced Nanocarrier

Platform for Herbal Drug Delivery . . . . . . . . . . . . . . . . . . . . . . . . .

351

Sumit Sharma, Sonali Batra, and V. R. Sinha

viii

Contents